Peculiarities of amnesia development after memory reconsolidation impairment by an АМРА glutamate receptors antagonist

On grape snails, the peculiaritites of amnesia development after the memory reconsolidation impairment by the AM-PA ((+) - a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate) glutamate receptors antagonist DNQX (6,7-Dinitroquinoxaline-2,3 (1H, 4H)-dione) were studied. Combined presentation of a banana (conditioned stimulus) with electric shock led to an increase in latencies of consummatory reactions from 20-35 s to 100-120 s (training criterion). Two days after training, animals were injected with DNQX and memory reconsolidation was induced (presentation of reminding conditioned stimuli). Testing snails after 1 and 10 days revealed the amnesia development: the latencies of reactions to the conditioned stimulus (20-40 s) did not differ from those to the differentiating stimulus (boiled carrots; p>0.1). Second training 10 days after the amnesia induction did not lead to the longterm memory formation, despite the fact that the number of conditioned and reinforcing stimuli combinations was greater than during the initial training. At the same time, during second training, the short-term memory formation was revealed. It is suggested that the impairment of conditioned food aversion memory reconsolidation by the AM-PA glutamate receptors antagonist causes the formation of specific anterograde amnesia, which is based on selective, dependent on the transcription processes changes in the neurons synaptic connections plasticity.