Breast cancer recurrence in postoperative scar and outside of it in patients with different menstrual function

Surgical specimens from 511 patients aged from 35 to 80 years (median age 52,9 ± 9,6 years) with invasive ductal breast cancer were studied. Neoadjuvant chemotherapy was given to 380 patients, of them, 74 % underwent radical surgery and the remaining patients received organ-preserving treatment. Postoperative adjuvant treatment was administered to 96 % of the patients. Local recurrence occurred in 67 patients within 3 to 66 months after surgery. Recurrence occurred much more frequently in patients with preserved menstrual function. Location of local recurrence depended on the extent of surgery. Recurrence in the area of postoperative scar was observed more frequently after radical mastectomy, while recurrence outside the postoperative scar occurred more frequently after organ-preserving treatment. Recurrence in the area of postoperative scar was associated with a large size of primary tumor. Neoadjuvant chemotherapy was found not to influence on the frequency of local breast cancer recurrence.