Сharacteristics of redox -depended modification of proteins in erythrocytes of patients with non -small cel lung cancer in relation with stage of the disease

The aim of the study was to investigate level of markers of oxidative modification of proteins in erythrocytes of patients with non-smallcell lung cancer. 108 patients with lung carcinoma were chosen for study. We measured proteins carbonyl derivatives, middle molecular peptides, SH-groups of proteins. The most increase of redox-depended modification of proteins is happened on II and IV stage of the desease. Oxidative modification of proteins in erythrocytes plays role in disregulation of their function and leads to different hematological disorders which intensity changes in relation with stage of lung cancer.