Features of the course of nephrotic syndrome in children with background pathology in the conditions of the fergana valley

The purpose of the study is to study the features of the course of nephrotic syndrome in children with background pathology in the conditions of the Ferghana Valley. We examined 34 children aged 3 to 12 years old, living in the industrial region of the Ferghana Valley and suffering from nephrotic syndrome (nephrotic form of chronic glomerulonephritis). Of these: 1-group - NS with AD; 2-group-NS without AD. The control group consisted of 25 practically healthy children of the same age. It has been shown that in children with NS against the background of AD, the development of immunopathological changes is interrelated with the clinical manifestations of atopy according to SCORAD, the production of IgE by plasma cells, the activation of T-cell clones (Th1, Th2) and hyperproduction of IL-4. In the conditions of the Fergana Valley, the immune status in children with NS against the background of AD is characterized by the development of multi-link (cellular, humoral, hyperproduction of IL-4) immunological deficiency, which persists during the period of remission of the disease. An increase in blood levels of IgE, ASL of the kidneys, hyperproduction of IL-4 and CEC concentrations are as a criterion for early immunodiagnosis in NS against the background of AD.