Inflammatory infiltration in stroma of invasiva ductal breast carcinoma in development of recurrence

Surgical specimens from 29 patients with stage T1-3N0-2M0breast cancer were studied. All patients were divided into 2 groups depending on the presence or absence of local recurrences. Group I comprised 16 patients having no disease progression. Group II consisted of 13 women with local recurrence. The presence of cells expressing CD3, CD4, CD8, CD68 and CD20 in inflammatory infiltrate close to different types of infiltrative component structures and far from them was studied in the primary tumor. It was shown that in cases with breast cancer recurrence, heterogeneous inflammatory infiltrate (scant by composition and distinguishable depending on the type of tumor structures) was observed more frequently in the primary tumor stroma. Maximum deficiency of effector cells was observed close to discrete tumor elements. Changes in the character of inflammatory reaction close to but not far from tumor elements can likely be considered as one of the risk factors for disease recurrence.