Acute inhalation toxicity of «Sv»

The purpose of the study is to study the acute inhalation toxicity of a drug coded «SV», developed at the FSBSI «FCTRBS-ARRVI», for group prevention and treatment using the method of dry hoof baths of infectious diseases of the distal limbs of cattle. For the experiment, 3 groups of white rats were formed - 2 experimental and control. Animals were transferred to inhalation priming chambers. In the first chamber with rats, the «SV» agent was sprayed at a concentration of 25.0 g/m3, in the second chamber - 50.0 g/m3. The rats of the control group were also placed in the inhalation chamber, but without spraying the product. The exposure in the chamber was 4 hours; the animals were observed for the next 14 days. Throughout the entire observation period, the general condition of the animals in all groups remained satisfactory, there was no mortality, and due to its absence, the hazard class according to GOST 32646-2014 is not determined. Biochemical, hematological and pathomorphological parameters of rats in the experimental groups did not differ significantly from the control group and were within the reference values. Thus, the inhalation method of exposure did not have a negative effect on the animals. These data allow us to consider «SV» as a promising means for group prevention and treatment of infectious diseases of the distal limbs of cattle using the dry hoof bath method, after further comprehensive study of general and specific toxicity.