Acute toxicity and articaine D-S Forte cumulation in different ways of administration

The paper presents results of a study of acute toxicity and cumulative properties of articaine at different routes of administration in mice. The experiment found that the maximum tolerated dose of articaine D-S Forte for mice with intraperitoneal administration is 240mg / kg, LD16 = 253.24; average lethal dose LD50 = 266,67 ± 2,76, absolutely lethal dose - 290mg / kg, and the coefficient of cumulation is Cc = 5.48. The maximum tolerated dose when administered intramuscularly for mice is 150 mg / kg LD16 = 203 mg / kg LD50 = 255 ± 21,71mg / kg and LD100 - 400mg / kg.