Acute kidney injury in patients with myocardial infarction and new coronavirus infection (COVID-19)

Acute kidney injury is a common pathological condition that complicates various diseases and affects both the short-term and long-term prognosis. There is ample research which testifies the unfavorable prognostic role of acute kidney injury in patients with myocardial infarction. The problem of acute kidney injury has become especially relevant during the COVID-19 pandemic, periodic outbreaks of which associated with new virus mutation are still observed. COVID-19 can both destabilize the existing pathology and lead to the development of new diseases, including myocardial infarction. In patients with myocardial infarction and COVID-19, a multiplicative risk effect of getting acute kidney injury is expected, the mechanism of which is likely to be different in each particular case: COVID-19 can simultaneously lead to a combination of renal and cardiac complications; acute kidney injury can develop due to heart failure, direct heart injury or myocardial infarction regardless of the new coronavirus infection. The article reviews the studies on the correlation between creatinine levels, renal dysfunction and the risk of myocardial infarction in COVID- 19 patients. The authors describe the pathophysiological basis of cardiorenal correlation in COVID-19, which is characterized by the complexity and uniqueness of changes.