Long-term outcome after endovascular treatment of coronary in-stent restenosis by paclitaxel-eluting balloons

The aim of the study was to evaluate the efficacy and safety of paclitaxel-eluting balloons (PEB) in the treatment of in-stent restenosis (ISR). Materials and Methods: study included 50 patients with CAD, which performed balloon angioplasty at the local and diffuse ISR. In the group of local ISR we used PEB DIOR (EuroCor, Germany) and SeQuent Please (BBraun, Germany). In the group of diffuse ISR we used 2 different PEB and the double-balloon catheter (DBC) Genie (Acrostak, Switzerland). Intravascular ultrasound before and after surgery was performed in all cases. The main study endpoints were the in-stent and in-segment late lumen loss (LLL), as well as the development of binary restenosis (BR) at follow-up examination in 6-9 months. Results: statistically significant differences in in-stent and in-segment LLL in a group of local ISR were not detected (p > 0.05). The development of BR was observed in 20% of cases in the subgroup DIOR and 10% of cases in the subgroup SeQuent Please. Statistically significant differences in in-stent and in-segment LLL in a group of local ISR were detected between 2 subgroups PEB and DBC Genie (p