Patent foramen ovale and migraine in ischemic stroke patients: incidence, pathogenetic interrelation and the effects of endovascular closure

BACKGROUND: Migraine is a chronic neurovascular disease with high incidence rate and medical-social significance. Despite more than half a century of studying the disease, the pathogenesis of migraine is not yet completely clear. The results of separate research works demonstrate the inter-relation of migraine with the presence of patent foramen ovale and circulation shunting from the right side to the left one.