Oxidative stress induced lipid peroxidation and DNA adduct formation in the pathogenesis of multiple myeloma and lymphoma
Автор: Tandon Ravi, Bhakar Mahima, Pande Deepti, Karki Kanchan, Negi Reena, Khanna H.D.
Журнал: Журнал стресс-физиологии и биохимии @jspb
Статья в выпуске: 1 т.9, 2013 года.
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Objective: To access the oxidative stress status by quantification of byproducts generated during lipid peroxidation and DNA breakdown products generated during DNA damage in the blood serum of multiple myeloma and lymphoma patients. Material & Methods: Case control study comprised of 40 patients of multiple myeloma and 20 patients of lymphoma along with 20 age and sex-matched healthy subjects as controls. Levels of Malondialdehyde and 8-hydroxy-2-deoxy-Guanosine were measured to study the oxidative stress status in the study subjects. Results: The level of markers of DNA damage and lipid peroxidation were found to be raised significantly in the study subjects in comparison to healthy controls. The results indicate oxidative stress and DNA damage activity increase progressively with the progression of disease. Conclusion: Oxidative stress causes DNA damage and Lipid peroxidation which results in the formation of DNA adducts leading to mutations thereby indicate the role of oxidative stress in the pathogenesis of multiple myeloma and lymphoma.
Oxidative stress, malondialdehyde, 8-hydroxy-2-deoxy-guanosine, multiple myeloma, lymphoma
Короткий адрес: https://sciup.org/14323703
IDR: 14323703
Список литературы Oxidative stress induced lipid peroxidation and DNA adduct formation in the pathogenesis of multiple myeloma and lymphoma
- Basu, A.K., Loechler, E.L., Leadon, S.A. and Essigmann, J.M (1989) Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies. Proc. Natl. Acad. Sci. U.S.A. 86, 7677-7681
- Burge, J.A and Aust, S.D (1978) Microsomal lipid peroxidation. Methods Enzymology 52, 302-310
- Flohe, L., Beckmann, R., Giertz, H. and Loschen, G (1985) Oxygen-centered free radicals a mediatorof inflammation. Sies H (Ed) Oxidative Stress. Academic Press, New York, 405-437
- Freeman, B.A. and Crapo, J.D (1982) Biology of disease: free radicals and tissue injury. Lab Invest., 47, 412-426.
- Halliwell, B. and Gutteridge, J (1999) Free radicals in biology and medicine. NY:Oxford Univ. Press.
- Hwang, E.S. and Bowen, P.E (2007) DNA damage, a biomarker of carcinogenesis: Its measurement and modulation by diet and environment. Crit Rev Food Sci Nutr, 47, 27-50.
- Ishikawa, K., Takenaga, K., Akimoto, M., Koshikawa, N., Yamaguchi, A., Imanishi, H.,Nakada, K., Honma, Y and Hayashi, J (2008) ROS-generating mitochondrial DNAmutations can regulate tumor cell metastasis. Science, 320, 661-664.
- Kasai, H., Hayami, H., Yamaizumi, Z., Saito, H and Nishimura, S. (1984) Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives. Nucl. Acids Res. 12, 2127-2136.
- Kasai, H. and Nishimura, S. (1984) Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucl. Acids. Res. 12, 2137-2145.
- Kumar, B., Koul, S., Khandrika, L., Meacham, R. B and Koul, H. K (2008) Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res 68, 1777-85.
- Marnett, L.J (2000) Oxy-radicals and DNA damage. Carcinogenesis 21(3), 361-370.
- Marnett, L.J., Riggins, J.N and West, J.D (2003) Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. J. Clin. Invest. 111, 583-593.
- Márquez, A., Villa-Treviño, S. and Guéraud, F. (2007) The LEC rat: a useful model for studying liver carcinogenesis related to oxidative stress and inflammation. Redox Rep., 12, 35-39.
- Ottaviano F.G., Handy, D.E. and Loscalzo, J. (2008) Redox regulation in the extracellular environment. Circ. J., 72, 1-16.
- Poulsen, H.E., Prieme, H. and Loft, S. (1998) Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prev. 7, 9-16.
- Shigenaga, M.K. and Ames, B.N. (1991) Assay for 8-hydroxy-2’-deoxyguanosine: a biomarker of invivo oxidative damage. Free Radical Biol Med, 10, 211-216.
- Valko, M., Rhodes, C.J., Moncol, J., Izakovic, M. and Mazur, M. (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. ChemBiol Interact 160, 1-40.
