Obesity and urolithiasis

In this study we have investigated 54 patients with urolithiasis, 21 female and 33 male patients with the age range of 21-74 year. Sixteen women had calcium-oxalate stones, five -mixed stones with calcium-phosphate component - carbonapathite. Twenty five male patients had calcium-oxalate stones, eight - mixed with the presence of carbonapathite. The investigation included the measurement of the waist circumference and the assessment of the 8 biochemical parameters: serum concentration of the urea, creatinine, uric acid, glucose, endogen creatinine clearance and renal 24-hour uric acid excretion, total calcium, non-organic phosphates. Functional state of the kidneys and serum concentration of the glucose were in normal ranges for all patients. Mean concentration of the total cholesterine in female patients was 5.49 mmol/l, in male patients -5.66 mmol/l. The patient set was divided in 2 groups according to the normal and increased waist circumference. In women with calcium urolithiasis the correlation was present between the waist circumference and serum uric acid concentration. The correlation was also present between the waist circumference and 24-hour excretion of the uric acid, total calcium and non-organic phosphates in male patients. The results led to a conclusion regarding the presence of the relationship between the abdominal obesity and the state of purines metabolism in female patients and purines, phosphatecalcium metabolism in male patients with calcium involved urolithiasis.