Parameters of erythropoiesis and cytoarchitectonics of circulating erythrocytes in rat with ascites ovarian tumor

Developing neoplasm can affect the erythropoiesis of the tumor-bearer. It is found out that the degree and nature of such effect depend on tumor biological characteristics. The purpose of the study is to examine erythrocyte morphometric parameters and erythropoiesis change in tumor-bearing animals under neoplastic process development. Materials and Methods. Peripheral blood of experimental animals was used as trial material. Blood sampling was carried out during stationary (n=64) and terminal (n=64) tumor growth phases. Healthy adult rats (n=62) composed the control group. To assess erythropoiesis, the authors determined erythrocyte content, hemoglobin level, reticulocyte count, and erythropoietin concentration in the peripheral blood of tumor-bearing animals. Cytoarchitectonics was studied using atomic force microscopy. Results. Significant reduction in the number of red blood cells and decrease in hemoglobin level was established. The erythropoietin level in blood plasma increased during the stationary phase as well as the number of reticulocytes in blood during all periods of tumor growth...