Parameters of acute toxicity and local irritating action of aminoseletone drug

The article presents the results of the parameters of acute toxicity and local irritating action of the tissue preparation aminoceletone study. The studies of acute toxicity were conducted on the laboratory animals - mice, rats. There were no signs of neurotoxicity or other vegetative symptoms. Thus, aminoseletone showed no toxic effects in acute experiment. LD50 could not be determined, as in intragastric, subcutaneous and intraperitoneal introduction of the drug in the maximum permissible amounts and in the dose range from 3000 to 28000 mg/kg of the body weight no animal death was observed. The studies of the local irritating properties of the tissue preparation were performed by means of skin application, intradermal and conjunctival tests. The experiment was conducted on the rabbits with a body weight of 2.2-2.4 kg, formed in the group of experiment and control. No reaction was observed in visual evaluation of the eye mucosa and skin condition. It is revealed that aminoseletone has no local irritating properties when cutaneous application, subcutaneous injection and conjunctival sample. The results of the research aminoseletone related to low-hazard substances according to the classification of I. V. Berezovskaya (2003).