Pathophysiology of hemorrhagic shock in conditions of extreme ambient temperatures (experimental study)

Purpose. The purpose of this work was the experimental assessment of the pathophysiological features of the course of traumatic shock under conditions of extreme ambient temperatures.Materials and methods. The experiment was carried out on 24 large animals (pigs) weighing 45-50 kg. The research was carried out in accordance with the directive 2010/63 / EU of the European Parliament and of the Council of the European Union on the protection of animals used for scientific purposes, 2012.Results. Disorders of the acid-base state are more pronounced in animals in the group exposed to high ambient temperatures. 30 minutes after exposure to high or low temperatures, the indicators in arterial blood were: base deficiency (-10) or (-4); pH -7.28 or 7.36; lactate - 12.44 or 11.25 mmol / l; the partial pressure of carbon dioxide is 38 or 26 mmHg, respectively. The survival rate of animals with hemorrhagic shock when exposed to high temperatures is lower than when exposed to low ambient temperatures (0 out of 4 and 2 out of 4 animals, respectively).Conclusion. Infusion therapy can reduce mortality when exposed to high and low temperatures. When providing assistance to the injured and wounded, it is necessary to take measures to protect them from high-temperature and low-temperature environmental factors, using shelters and thermal insulation blankets. These measures will reduce the consequences of blood loss and lead to a more favorable course of traumatic illness.