Pathogenetic correction of cytokine disbalance in experimental posttraumatic arthritis

In case of traumatic joint damage, developing aseptic inflammation leads to cytokine imbalance. The goal of this paper is to study the effect of oral nimesulide administration and intra-articular ozone administration on cytokine profile in experimental posttraumatic arthritis. Materials and Methods. The authors modelled traumatic joint damage in 72 white rats. The animals were divided into 3 groups. Group 1 consisted of 12 intact rats. In Group 2 (30 rats) and Group 3 (30 rats) the modeling of joint damage was achieved. Group 2 did not receive any treatment. In Group 3, oral administration of nimesulide (2 mg/kg per 10 days) and intra-articular administration of the ozone-oxygen mixture in ozone concentration (15 mg/l, 5 sessions) were administered. The cytokine profile was assessed by the content of proinflammatory (IL-1β, TNF-α, IL-6, IL-17), anti-inflammatory (IL-4, IL-10) and regulatory (IL-2) cytokines by enzyme-linked immunosorbent assay. The statistical processing of the results was carried out using Student's t-test...