Pathogenesis aspects of formation of the disadaptation changes of cardiovascular system, coursed by intensive physical activities

Introduction. Over recent years one of the topical issues in Russia is the assessment of cardiovascular system of the people with intense physical activity. The complexity of this issue is caused by the challenges in understanding of how pathological changes in heart may lead to sudden cardiac death. Materials and Methods. The research consists of experimental and clinical assessments. In the experimental part of assessment mice were exposed to rigorous exercise. In the clinical part 142 adolescents engaged in regular sports activities were examined using such methods as lab test and special exam. Results. It has been established that rigorous exercise of laboratory animals leads to the development of ultrastructural myocardial injuries and adrenaline burst. Abovemen-tioned changes correlate to survival rate of the animals. Clinical observations revealed that regular exercises stimulated the development of myocardial hypertrophy, vegetative disturbances, and changes in biochemical values. Discussion and Conclusions. It was shown that besides myocardial hypertrophy and hemodynamic disorders there are also other pathophysiological mechanisms that cause the development of maladaptation abnormalities in cardiovascular system.