Pathogenetic factors of enamel formation abnormalities

The article discusses the etiology and pathogenesis of imperfect amelogenesis associated with the genome. It is described that the first genetic association is determined by the discovery of an amelogenin gene present in the region P21.1-22.3 on the X chromosome. The role of the second gene involved in the formation of the disease picture, the enamel new gene on chromosome 4 (4q21), is considered. The characteristic of existing classifications based on clinical data or on data combining information about clinical manifestations of the disease and genetic etiology is given.