Pathogenetic mechanisms of regeneration of the dermis after implantation of the threadsis based on polydioxanone

The article is devoted to studying of pathogenetic mechanisms of skin regeneration after the implantation of the filaments based on polydioxanone.The aim of the study: analysis of the effect of fibres based on polydioxanone, on the processes of biostimulation of the dermis.Design: prospective, independent, placebo-controlled study.Materials and methods: the authors performed a prospective, independent, placebo-controlled clinical and morphological study in the period 2015-2017, in which the conditions of voluntary informed consent were included 22 patients with age associated skin changes, ranging in age from 35 to 50 years. General morphological examination was performed on hematoxylin and eosin, and used histochemical staining of biopsy specimens according to the method of van Gieson, allowing you to visualize collagen and elastic fibers of the dermis. To assess the nature of intercellular cooperation of different cell lines visualized using immunohistochemical (IHC) techniques.The results showed that the basis of morphogenetic restructuring of the skin after implantation of filaments based on polydioxanone, is the activation of repair mechanisms through the inclusion of M2-macrophages. This process is manifested by angiogenesis through stimulation of VEGF expression and reorga- nization of the vascular bed of the skin and stimulation of the private reserve of cells fibroblastic series through the activation of the stromal vascular fraction. It should be noted that in addition to activation of neocollagenogenesis leading to the restructuring of the dermis and epidermis, the introduction of threads based on polydioxanone, has a positive impact on the balance of MMP/TIMR, limiting degradation mechanisms and contributing to the accumulation matrix of the connective tissue of the dermis.Conclusion: The results of the study allow us to conclude that the filament implant with filaments based on polydioxanone having pathogenetically substanti- ated pronounced regenerative effect on the dermis.