Pathogenetical grounds for effectiveness of mini-invasive interventions in emergency surgery

Introduction. The article deals with manifestations of the metabolic response to surgical treatment of acute destructive cholecystitis and peritonitis with various traumatization of the abdominal wall ("open" laparotomy wound or minimally invasive approach). Materials and Methods. The clinico-laboratory analysis of patients with acute cholecystitis volume and acute peritonitis was performed. All patients were operated with the necessary surgical intervention. The patients in the control groups were operated with a laparatomic operative approach, in the main groups, mini-invasive laparoscopic technology was used. The examination of patients of both groups was performed at admission and in the dynamics of the postoperative period (1st, 2nd, 4th, 6th day after the operation). In addition to routine biochemical blood tests in the patients, the intensity of endotoxemia (the plasma level was determined by the molecules of medium mass, total and effective albumin concentration), the peroxide oxidation of membrane lipids and the activity of superoxide dismutase and phospholipase A2 were assessed. Results. The decrease in the albumin toxicity index was observed with respect to control (in cholecystitis - by 25.1-37.7 % (p