Pathogenesis of changes and advanced techniques of immune status correction in premature newborns

Severe infections are the major reason of morbidity and mortality in premature newborns which is associated with immaturity of their immune system. If we understand the mecha-nisms of inborn and adaptive immunity forming in a premature newborn we will be able to develop effective diagnostic, preventive and therapeutic strategies. The aim of our work is to analyze the data from the up-to-date domestic and foreign literature dedicated to pathogenesis of changes and advanced techniques of immune status correction in premature newborns. Organization and methods of research involved critical analysis of up-to-date resources of medical information on pathogenesis of changes and advanced techniques of immune status correction in premature newborns for 2005 through 2015 given in Pubmed database. Results and discussion. Functional immaturity of inborn and adaptive immunity effectors, immune response dysregulation with polarization towards subpopulations of T-lymphocytes Th2- Treg and limited Th1- and Тh17-dependent reactions, on the one hand, are the basis of fetoplacental tolerance, and, in the other hand, impair anti-microbial response of the body, and account for neonatal morbidity and mortality, mostly in patients with sepsis, inadequate immunization response and underlying risk for allergies. From pathogenic standpoint the effective way to correct immune status in premature newborns is using interferon gamma, GM-CSF, glucocorticoids and other means. An advanced immune response modifier is probably erythropoietin that has pleiotropic effect, immunotropic in particular, which is being studied intensively at the moment.