Pathogenesis of cardiovascular diseases in centenarians

The problem of coronary heart disease (CHD) has acquired important medical and social significance in recent years. To understand the pathogenesis of coronary heart disease in the elderly, it is necessary to study circulatory regulation systems, in particular the sympathetic adrenal system (SAS). More informative and adequate is the simultaneous determination of the excretion of the precursor of catecholamine synthesis (KA) – dioxifylamine (DOPA) and its spectrum: dopamine (DA), norepinephrine (NA) and adrenaline (A). In the metabolism of biogenic amines, the reaction of their oxidative deamination, catalyzed by monoamine oxidase (MAO), is of key importance. The question of the relationship of KA with other hormones in coronary heart disease in modern cardiology remains insufficiently studied.