Pathomorphology of apostematous nephritis in cattle

The aim of the study is to analyze the pathomorphological changes in organs and tissues under purulent embolic nephritis in cattle, establish the etiopathogenesis of the disease and conduct differential diagnosis. The research has studied the pathomorphological changes in apostematous nephritis in a cow and established the characteristic pathognomonic macro- and microscopic signs of the underlying disease and of complications caused, as well as causation in between. Differential diagnosis of apostematous nephritis from other clinical and anatomical forms of nephritis was carried out. The objects of research were organs and tissues of a corpse of a Holstein black-and-white cow. The pathological autopsy was performed by the method of partial dismemberment of the organocomplex. During the section of the corpse, material was taken for histological examination - fragments of tissues of the kidneys, lungs, regional lymph nodes, myocardium, spleen, liver, brain, which was fi in 10 % neutral formalin solution, the sections were made on a microtome "Technom MZP-01", stained with hematoxylin Ehrlich and eosin, microscopy was performed using a Levenhuk 320 microscope. Microphotography and analysis of micrographs were performed on a Canon EOS 1100D camera. For differential diagnosis, the pathological material was sent to the laboratory; infection was excluded in all cases. The results of the study of organs and tissues showed that the main complication of purulent-catarrhal bronchopneumonia, which caused the fatal outcome of the disease, was acute bilateral apostematous nephritis, which developed as a result of metastatic drift of bacterial emboli into the vessels of the kidneys with subsequent damage to the glomerular and tubulo-interstitial apparatus, which together with hypoperfusion of the cortex against the background of bacterial-toxic shock caused the development of acute renal failure and uremic syndrome. The key pathomorphological signs of apostematous nephritis are multiple foci of purulent infl in the renal cortex, primary lesion of the glomeruli, degenerative-necrotic changes in tubular epithelial cells, and the presence in the body of an extensive focus of purulent infl chronologically preceding nephritis in combination with the absence of general septic changes. The data obtained expand the understanding of the etiopathogenesis and morphology of apostematous nephritis, which will optimize the methods used for the intravital and postmortem diagnosis of the disease.