Периферические биологические факторы и биомаркеры суицида

Автор: Розанов Всеволод Анатолиевич

Статья в выпуске: 1 (30) т.9, 2018 года.

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При обсуждении биологических факторов и патофизиологических механизмов суицидального поведения нельзя ограничиваться только анализом процессов в ЦНС. Как свидетельствуют многочисленные данные, в патологические цепочки вовлекаются разнообразные периферические процессы - метаболические системы организма (в частности, периферические серотонин, триптофан, нейрокинуренины, норепинефрин и др.), липидный обмен, иммунитет (в частности, система цитокинов), нейрогормональные реакции, а также кишечная микрофлора как компонент оси «кишечник-мозг». Все они, а также их генетические маркеры, в конечном итоге оказываются так или иначе связанными с суицидальным поведением - от суицидальных мыслей до завершенного суицида. Что при этом является причиной, а что следствием - дифференцировать довольно затруднительно. Скорее всего, эти связи многосторонние и носят сетевой характер. Интегрирующим механизмом, наиболее вероятно, является стресс-реакция, охватывающая весь организм и затрагивающая физиологические процессы, сознание, поведение и мышление. Это имеет значение одновременно и для понимания патофизиологии суицидальности, и для поиска периферических маркеров, которые могли бы быть использованы для уточнения риска, предикции и превенции самоубийств. Наиболее перспективным является комбинирование социальных, психологических, биохимических и генетических тестов, и совершенствование стратегий, аналогичных конвергентной функциональной геномике.

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Самоубийство, биологические механизмы, серотонин, норадреналин, триптофан, нейрокинуренины, воспаление, цитокины, стресс-реакция, липиды, ось "кишечник-мозг", кожно-гальваническая реакция, генетические маркеры, тесты на суицидальность

Короткий адрес: https://sciup.org/140225872

IDR: 140225872

Список литературы Периферические биологические факторы и биомаркеры суицида

Mann J.J. Neurobiology of suicidal behavior. Nature Reviews Neuroscience. 2003; 4: 819-28.
Heeringen van K., Mann J.J. The neurobiology of suicide. The Lancet Psychiatry. 2014; 1 (1): 63-72.
Wasserman D. A stress-vulnerability model and the development of the suicidal process. In D. Wasserman (ed.) Suicide. An Unnecessary Death, 2001, London: Martin Duniz. pp. 13-27.
Vitetta L., Anton B., Cortizo F. et al. Mind-body medicine: stress and its impact on overall health and longevity. Ann. NY. Acad. Sci. 2005; 1057: 492-505.
Pandey G.N., Dwivedi Y. Peripheral Biomarkers for Suicide. In: The Neurobiological Basis of Suicide/Ed. Yogesh Dwiwedi. Boca Raton (FL): CRC Press/Taylor & Francis. 2012.
Arantes-Goncalves F., Coelho R. Seeking for biological markers in suicidal behavior. Acta Med Port. 2008; 21 (1): 89-97.
Oquendo M.A., Bernanke J.A. Suicide risk assessment: tools and challenges. World Psychiatry. 2017; 16 (1): 28-29.
Mann J.J., Arango V., Underwood M.D. Serotonin and suicidal behavior. Ann. NY. Acad. Sci. 1990; 600: 476-84.
van Heeringen C. Suicide, serotonin, and the brain//Crisis. -2001. -V.22(2). -P.66-70.
Barchas J.D., Altemus M. Monoamine hypotheses of mood disorders. In: Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition. Eds: G.J. Siegel, B.W. Agranoff, D. R.W. Albers et al. Philadelphia: Lippincott-Raven; 1999. assessed at: https://www.ncbi.nlm.nih.gov/books/NBK28257/
Stahl S.M. Mechanism of action of serotonin selective reuptake inhibitors. J. Affect. Dis. 1998; 51 (3): 215-35.
Shaw D.M., Camps F.E., Eccleston E.G. 5-hydroxytryptamine in the hindbrain of depressive suicides. British Journal of Psychiatry. 1967; 113: 1407-11.
Asberg M., Traskman L., Thoren P. 5HIAA in the cerebrospinal fluid: a biochemical suicide predictor. Archives of General Psychiatry. 1976; 33: 1193-97.
Arita H. The neuroscience of suicide. Brain Nerve. 2012; 64 (8): 929-35.
Mann J.J. The serotoninergic system in mood disorders and suicidal behavior. Philosophical Transactions of the Royal Society B: Biological Sciences. 2013; 368 (1615): 20120537.
Розанов В.А., Моховиков А.Н., Вассерман Д. Нейробиологические основы суицидальности. Укр. Мед. Журн. 1999; 6 (14): 5-12.
Розанов В.А. Гены и суицидальное поведение. Суицидология. 2013; 4 (10), 1: 3-14.
Antypa N., Seretti A., Rujesku D. Serotonergic genes and suicide: a systematic review. Eur. Neuropsychopharmacol. 2013; 23 (10): 1125-42.
Uher R., Zwicker A. Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness. World Psychiatry. 2017; 16 (2): 121-9.
Heils A., Teufel A., Petri S. et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996; 66: 2621-4.
Caspi A., Sugden K., Moffitt T.E. et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003; 301: 386-9.
Lin P.Y., Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: results of meta-analysis. Biological Psychiatry. 2004; 55: 1023-30.
Wasserman D., Sokolowski M., Wasserman J. et al. Neurobiology and the genetics of suicide. In: Oxford Textbook on Suicidology and Suicide Prevention (Ed. D.Wasserman and C.Wasserman), 2009, NY: Oxford University Press, pp.165-182.
Li D., He L. Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses. Human Genetics. 2006; 119: 233-40.
Kenna G.A., Roder-Hanna N., Leggio L. et al. Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy. Pharmacogenomics Pers. Med. 2012; 5: 19-35.
Tyano S., Zalsman G., Ofek H. et al. Plasma serotonin levels and suicidal behavior in adolescents. Eur. Neuropsychopharmacol. 2006; 16: 49-57.
Berger M., Gray J.A., Roth B.L. et al. The expanded biology of serotonin. Annu. Rev. Med. 2006; 60: 355-66.
Pandey G.N. Altered serotonin function in suicide. Evidence from platelet and neuroendocrine studies. Ann. NY. Acad. Sci. 1997; 836: 182-200.
Verkes R.J., Van der Mast R.C., Kerkhof A.J. et al. Platelet serotonin, monoamine oxidase activity, and paroxetine binding related to impulsive suicide attempts and borderline personality disorder. Biol Psychiatry. 1998; 43 (10): 740-6.
Verkes R.J., Fekkes D., Zwinderman A.H. et al. Platelet serotonin and paroxetine binding correlate with recurrence of suicidal behavior. Psychopharmacology (Berl). 1997; 132 (1): 89-94.
Pandey G.N., Pandey S.C., Dwivedi Y. et al. Platelet serotonin-2A receptors: A potential biological marker for suicidal behavior. Am J Psychiatry. 1995; 152: 850-5.
Mann J.J., McBride A., Brown R. Relationship between central and peripheral serotonin indexes in depressed and suicidal patients. Arch Gen Psychiatry. 1992; 49 (6): 442-6.
Müller-Oerlinghausen B., Roggenbach J., Franke L. Serotonergic platelet markers of suicidal behavior -do they really exist? J Affect Disord. 2004; 79 (1-3): 13-24.
Roggenbach J., Müller-Oerlinghausen B., Franke L. et al. Peripheral serotonergic markers in acutely suicidal patients. 1. Comparison of serotoninergic platelet measures between suicidal individuals, non-suicidal patients with major depression and healthy subjects. J Neural Transm. 2007; 114 (4): 479-87.
Ragolsky M., Shimon H., Shalev H. et al. Suicidal thoughts are associated with platelet counts in adolescent inpatient. J Child Adolesc. Psychopharmacol. 2013; 23: 49-53.
Lesch K.P., Wolozin B.L., Murphy D.L. et al. Primary structure of the human 162 K.-P. Lesch et al.: Organization of the human serotonin transporter gene platelet serotonin (5-HT) uptake site: identity with the brain 5-HT transporter. J Neurochem. 1993; 60: 2319-22.
Coccaro E.F., Berman M.E., Kavoussi R.J., Hauger R.L. Relationship of prolactin response to D-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men. Biol Psychiatry. 1996; 40: 157-64.
Malone K.M., Corbitt E.M., Li S, Mann J.J. Prolactin response to fenfluramine and suicide attempt lethality in major depression. British Journal of Psychiatry. 1996; 168: 324-9.
Cleare A.J., Murray R.M., O'Keane V. Reduced prolactin and cortisol responses to D-fenfluramine in depressed compared to healthy matched control subjects. Neuropsychopharmacology. 1996; 14: 349-54.
Нейрохимия/под ред. И.В. Ашмарина, П.В. Стукалова. М.: Изд-во ин-та биомед. химии РАМН, 1996. 470 с.
Spring B Recent research on the behavioral effects of tryptophan and carbohydrate. Nutr Health. 1984; 3 (1-2): 55-67.
Winberg S., Overli O., Lepage O. Suppression of aggression in rainbow trout (Oncorhynchus mykiss) by dietary L-tryptophan. J Exp Biol. 2001; 204 (Pt 22): 3867-76.
Wolkers C.P., Serra M., Hoshiba M.A. et al. Dietary L-tryptophan alters aggression in juvenile matrixa Brycon amazon-icus. Fish Physiol Biochem. 2012; 38 (3): 819-27.
Moskowitz D.S., Pinard G., Zuroff D.C. et al. The effect of tryptophan on social interaction in everyday life: a placebo-controlled study. Neuropsychopharmacology. 2001; 25 (2): 27789.
aan het Rot M., Moskowitz D.S., Pinard G. et al. Social behaviour and mood in everyday life: the effects of tryptophan in quarrelsome individuals. J Psychiatry Neurosci. 2006; 31 (4): 25362.
Bell C., Abrams J., Nutt D. Tryptophan depletion and its implications for psychiatry. Br J Psychiatry. 2001; 178: 399-405.
Russo S., Kema I.P., Fokkema M.R. et al. Tryptophan as a link between psychopathology and somatic states. Psychosom Med. 2003; 65 (4): 665-71.
Russo S., Kema I.P., Bosker F. et al. Tryptophan as an evolution-arily conserved signal to brain serotonin: molecular evidence and psychiatric implications. World J Biol Psychiatry. 2009; 10 (4): 258-68.
O'Mahony S.M., Clarke G., Borre Y.E. et al. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015; 277: 32-48.
Лапин И. П. Стресс. Тревога. Депрессия. Алкоголизм. Эпилепсия (Нейрокинурениновые механизмы и новые подходы к лечению). СПб.: Изд-во ДЕАН, 2004. 224 с.
Шилов Ю.Е., Безруков М.В. Кинуренины в патогенезе эндогенных психических заболеваний. Вестник РАМН. 2013; 1: 35-41.
Узбеков М.Г., Максимова Н.М. Моноамино-гормональные связи в патогенезе тревожной депрессии. Журнал Неврологии и Психиатрии. 2015; 1 (2): 52-5.
Dell'Osso L., Carmassi C., Mucci F. et al. Depression, Serotonin and Tryptophan. Current Pharmaceutical Design. 2016; 22: 949-54.
Ogawa S., Fujii T., Koga N. et al. Plasma L-tryptophan in major depressive disorder: new data and meta-analysis. J Clin Psychiatry. 2014; 75 (9): e906-15.
Fukuda K. Etiological classification of depression based on the enzymes of tryptophan metabolism. BMC Psychiatry. 2014; 14: 372.
Gabbay V., Klein R.G., Katz Y. et al. The possible role of the kynurenine pathway in adolescent depression with melancholic features. J Child Psychol Psychiatry. 2010; 51 (8): 935-43.
Almeida-Montes L.G., Valles-Sanchez V., Moreno-Aguilar J. et al. Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempt. J Psychiatry Neurosci. 2000; 25 (4): 371-7.
Sublette M.E., Galfalvy H.C., Fuchs D. et al. Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. Brain Behav Immun. 2011; 25 (6): 1272-8.
Bradley K.A., Case J.A., Khan O. et al. The role of the kynurenine pathway in suicidality in adolescent major depressive disorder. Psychiatry Res. 2015; 227 (2-3): 206-12.
Voracek M., Tran U.S. Dietary tryptophan and suicide rate in industrial nations. J Affect Disord. 2007; 98 (3): 259-62.
Мюльберг А.А., Гришина Т.В. Цитокины как медиаторы нейроиммунных взаимодействий. Усп. Физиол. Наук. 2006; 37 (1): 18-27.
Goldsmith D.R., Rapaport M.H., Miller B.J.A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016; 21 (12): 1696-709.
Soskin D.P., Cassiello C., Isacoff O. et al. The inflammatory hypothesis of depression. FOCUS. The Journal of Lifelong Learning in Psychiatry. 2012; 10 (4): 413-21.
Kohler O., Benros M.E., Nordentoft M. et al. Effect of antiinflammatory treatment on depression, depressive symptoms, and adverse effects. A systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry. 2014; 71 (12): 1381
Kim Y.K., Lee S.W., Kim S.H. et al. Differences in cytokines between non-suicidal patients and suicidal patients in major depression. Progress in Neuro-psychopharmacology and Biological Psychiatry. 2008; 32 (2): 356-61.
O'Donovan A., Rush G., Hoatam G. et al. Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depression and Anxiety. 2013; 30 (4): 307-14.
Mina V.A., Lacerda-Pinheiro S.F., Maia L.C.et al. The influence of inflammatory cytokines in physiopathology of suicidal behavior. J Affect Disord. 2015; 172: 219-30.
Janelidze S., Mattei D., Westrin A. et al. Cytokine levels in the blood may distinguish suicide attempters from depressed patients. Brain Behav Immun. -2011; 25 (2): 335-9.
Ganança L., Oquendo M.A., Tyrka A.R. et al. The role of cytokines in the pathophysiology of suicidal behavior. Psychoneuroendocrinology. 2016; 63: 296-310.
Тишкина А. О., Степаничев М. Ю., Аниол В. А. и др. Функции микроглии в здоровом мозге: фокус на нейропластичность. Успехи Физиологических Наук. 2014; 45 (4): 3-18.
Frick L.R., Williams K., Pittenger C. Microglial dysregulation in psychiatric disease. Clin Dev Immunol. 2013; 2013:608654
Kim J.W., Szigethy E.M., Melhem N.M. et al. Inflammatory markers and the pathogenesis of pediatric depression and suicide: a systematic review of the literature. J of Clinical Psychiatry. 2014; 75 (11): 1242-53.
Reus G.Z., Fries G.R., Stertz L. et al. The role of inflammation and microglia un the pathophysiology of psychiatric disorders. Neuroscience. 2015; 300: 141-54.
Bhattacharya A., Derecki N.C., Lovenberg T.W. et al. Role of neuro-immunological factors in the pathophysiology of mood disorders. Psychopharmacology. 2016; 233 (9): 1623-36.
Justo D., Arbel Y., Altberg G. et al. Inflammation markers in individuals with history of mental health crisis. Inflammation. 2008; 31 (4): 254-9.
Steiner J., Gos T., Bogerts B. et al. Possible impact of microglial cells and the monocyte-macrophage system in suicidal behavior. CNS Neurol Disord Drug Targets. 2013; 12 (7): 971-9.
Brisch R., Steiner J., Mawrin C. et al. Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders. Eur Arch Psychiatry Clin Neurosci. 2017; 267 (5): 403-15.
Александровский Ю.А., Чехонин В.П. Клиническая иммунология пограничных психических расстройств. М.: ГЭОТАР -МЕДИА, 2005. 256 с.
Гаркави Л.Х., Квакина Е.Б., Уколова М.А. Адаптационные реакции и резистентность организма. Ростов н/Д: Изд-во Ростовского университета, 1990. 224 с.
Ivkovic M., Pantovic-Stefanovic M., Dunjic-Kostic B. et al. Neutrophil-to-lymphocye ratio predicting suicide risk in euthymic patients with bipolar disorder: Moderating effect of family history. Compr Psychiatry. 2016; 66: 87-95.
Bryleva E.Y., Brundin L. Kynurenine pathway metabolites and suicidality. Neuropharmacology. 2017; 112, Part B: 324-30.
Kennedy P.J., Cryan J.F., Dinan T.G. et al. Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology. 2017; 112 (Pt B): 399-412.
Martin-Subero M., Anderson G., Kanchanatawan B. et al. Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolites and gut-brain pathways. CNS Spectr. 2016; 21 (2): 184-98.
Lundberg U. Stress, subjective and objective health. International Journal of Social Welfare. 2006; 15: 41-8.
Rozanov V. Stress and Epigenetics in Suicide. 1st Edition, Academic Press, 2017. 227 р.
Cole S.W. Social regulation of human gene expression: mechanisms and implications for public health. American Journal of PublicHealth. 2013; 103, Suppl 1: 84-92.
Cole S. W. Human Social Genomics. PLoS Genetics. 2014; 10 (8): e1004601.
Steinvil A., Shirom A., Melamed S. et al. Relation of educational level to inflammation-sensitive biomarker level. AM J Cardiol. 2008; 102 (8): 1034-9.
Muldoon M.F., Manuck S.B., Matthews K.A. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. British Medical Journal. 1990; 301: 30914.
Cummings P., Psaty B.M. The association between cholesterol and death from suicide and injury. Annals of Internal Medicine. 1994; 120: 848-55.
Lester D. Serum cholesterol levels and suicide: A meta-analysis. Suicide and Life Threatening Behavior. 2002; 32: 333-46.
Zhang J. Epidemiological link between low cholesterol and suicidality: a puzzle never finished. Nutritional Neuroscience. 2011; 14 (6): 268-87.
Rabe-Jablonska J., Poprawska I. Level of serum total cholesterol and LD-cholesterol in patients with major depression in acute period and remission. Med Sci Monit. 2000; 6 (3): 539-47.
Ploeckinger B., Dantendorfer K., Ulm M. et al. Rapid decrease of serum cholesterol concetnrations and postpartum depression. BMJ. 1996; 313 (7058): 664-664.
Golomb B.A. Cholesterol and violence: is there a connection? Annals of Internal Medicine. 1998; 128 (6): 478-87.
Розанов В.А., Мидько А.А. Системный липидный обмен и суицидальное поведение. Нейронауки. 2006; 4 (6): 3-13.
Spedding S.Vitamin D and depression: A systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. 2014; 6 (4): 1501-8.
de Leon J., Mallory P., Maw L. et al. Lack of replication of the association of low serum cholesterol and attempted suicide in another country raises more questions. Ann Clin Psychiatry. 2011; 23 (3): 163-170.
Cantarelli M.G., Tramontina A.C., Leite M.C. et al. Potential neurochemical links between cholesterol and suicidal behavior. Psychiatry Res. 2014; 220 (3): 745-751.
Colin A., Reggers J., Castronovo V. et al. Lipids, depression and suicide. Encephale. 2003; 29 (1): 49-58.
Montgomery P., Richardson A.J.Omega-3 fatty acids for bipolar disorder. The Cochrane Database of Systematic Reviews. 2008; 16 (2): CD005169.
Chang S.S., Wen C.P., Tsai M.K. et al. Adiposity, its related biologic risk factors, and suicide: a cohort study of 542088 taiwanese adults. Am J Epidemiol. 2012; 175 (8): 804-15.
Charmandari E., Tsigos C., Chrousos, G. P. Endocrinology of the stress response. Annual Reviews in Physiology. 2005; 67: 259-84.
Yerevanian B.I., Feusner J.D., Koek R.J., Mintz J. The dexamethasone suppression test as a predictor of suicidal behavior in unipolar depression. J Affect Disord. 2004; 83: 103-8.
Coryell W., Schlesser M. The dexamethasone suppression test and suicide prediction. Am J Psychiatry. 2001; 158: 748-53.
van Heeringen K., Audenaert K., Van de Wiele L., Verstraete A. Cortisol in violent suicidal behaviour: Association with personality and monoaminergic activity. J Affect Disord. 2000; 60: 181-9.
Thorell L.H. Valid electrodermal hyporeactivity for depressive suicidal propensity offers links to cognitive theory. Acta Psychiatr Scand. 2009; 119: 338-49.
Thorell L.H., Wolfersdorf M., Straub R. et al. Electrodermal hyporeactivity as a trait marker for suicidal propensity in uni-and bipolar depression. J Psychiatr Res. 2013; 47: 1925-31.
Психофизиология: Учебник для ВУЗов. 4-е изд./Под ред. Ю.И. Александрова, СПб: Питер, 2014. 464 с.
Sarchiapone M., Iosue M., Carli V. et al. EUDOR-A multicentre research program: A naturalistic, European Multi-centre clinical study of EDOR test in adult patients with primary depression. BMC Psychiatry. 2017; 17: 108.
Culver A. Letter to the Editor: Specificity of electrodermal reactivity testing for suicidal propensity in Thorell et al. J Psychiatr Res. 2014; 55: 133-133.
Wasserman D., Sokolowski M., Rozanov V. et al. The CRHR1 gene: A marker for suicidality in depressed males exposed to low stress. Genes, Brain and Behavior. 2008; 7 (1): 14-9.
Wasserman D., Wasserman J., Rozanov V. et al. Depression in suicidal males: genetic risk variants in the CRHR1 gene. Genes, Brain and Behavior. 2008; 8 (1): 72-9.
Wasserman D., Sokolowski M., Wasserman J., Rozanov V. Genetic variation in the hypothalamic-pituitary-adrenocortical axis regulatory factor, T-box 19, and the angry/hostility personality trait. Genes, Brain and Behavior. 2007; 6: 321-8.
Rozanov V.A., Mid'ko A. Personality patterns of suicide attempters: gender differences in Ukraine. Spanish Journal of Psychology. 2011; 14 (2): 693-700.
Wasserman D., Geijer T., Rozanov V. et al. Suicide attempt and basic mechanisms in neural conduction: Relationships to the SCN8A and VAMP4 genes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2005; 133 B (1): 116-9.
Mirkovic B., Laurent C., Podlipski M.A. et al. Genetic association studies of suicidal behavior: A review of the past 10 years, progress, limitations, and future directions. Frontiers in Psychiatry. 2016; 7: 158.
Patel S.D., Le-Niculescu H., Koller D.L. et al. Coming to grips with complex disorders: genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics. Am J Med Genet B Neuropsychiatr Genet. 2010; 153 B (4): 850-77.
Le-Niculescu H., Levey D.F., Ayalew M. et al. Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry. 2013; 18 (12): 1249-64.
Niculescu A.B., Levey D.F., Phalen P.L. et al. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Mol Psychiatry. 2015; 20 (11): 1266-85.
Levey D.F., Niculescu E.M., Le-Niculescu H. et al. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Mol Psychiatry. 2016; 21 (6): 768-85.
Niculescu A.B., Le-Niculescu H., Levey D.F. et al. Precision medicine for suicidality: from universality to subtypes and personalization. Mol Psychiatry. 2017; 22 (9): 1250-73.
Kaminsky Z., Wilcox H.C., Eaton W.W. et al. Epigenetic and genetic variations at SKA2 predict suicidal behavior and post-traumatic stress disorder. Translational Psychiatry. 2015; 5: e627.
Guintivano J., Brown T., Newcomer A. et al. Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. American Journal of Psychiatry. 2014; 171: 1287-96.
Sagar R., Pattanyak R.D. Potential biomarkers for bipolar disorder: Where do we stand? Indian J Med Res. 2017; 145 (1): 7-16.

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