Personalized aspects of idiopathic osteoarthrosis of the hip joint

Objective To reveal personalized predictive criteria of idiopathic osteoarthrosis of the hip joint. Material and methods The study included 100 unrelated patients with grade III-IV idiopathic osteoarthritis of the hip joint, aged 61.3 ± 8.5 years, Russian citizens of Zabaykalsky Krai. Control group consisted of 100 patients of matching age (60 ± 8.3 years), ethnic background and geographic range. Exclusion criteria for the patients were other types of osteoarthritis (post-traumatic, rheumatoid, etc.), acute inflammatory diseases and exacerbations of chronic conditions, and osteoporosis. Clinical, laboratory (polymorphism of genes determined for TLR2-753Arg > Gln, TLR6-249Ser > Pro, FCGR2A-166His > Arg, DEFB1-52G > A, DEFB1-20G > A, TGFb1-25Arg > Pro, TNFα-308G > А, IL4-589C > Т) and radiological methods were employed in the study. Results Statistically significant differences between patients with idiopathic coxarthrosis and control group were observed in carriers of -166Arg genotype / Arg FCGR2A gene (χ2 - 99.2, p