Personalized aspects of idiopathic osteoarthrosis of the hip joint
Автор: Miromanov Alexander M., Zabello Trofim V., Dorzheev Vladimir V., Miromanova Natalia A., Emelianov Artur S.
Журнал: Гений ортопедии @geniy-ortopedii
Рубрика: Оригинальные статьи
Статья в выпуске: 3, 2017 года.
Бесплатный доступ
Objective To reveal personalized predictive criteria of idiopathic osteoarthrosis of the hip joint. Material and methods The study included 100 unrelated patients with grade III-IV idiopathic osteoarthritis of the hip joint, aged 61.3 ± 8.5 years, Russian citizens of Zabaykalsky Krai. Control group consisted of 100 patients of matching age (60 ± 8.3 years), ethnic background and geographic range. Exclusion criteria for the patients were other types of osteoarthritis (post-traumatic, rheumatoid, etc.), acute inflammatory diseases and exacerbations of chronic conditions, and osteoporosis. Clinical, laboratory (polymorphism of genes determined for TLR2-753Arg > Gln, TLR6-249Ser > Pro, FCGR2A-166His > Arg, DEFB1-52G > A, DEFB1-20G > A, TGFb1-25Arg > Pro, TNFα-308G > А, IL4-589C > Т) and radiological methods were employed in the study. Results Statistically significant differences between patients with idiopathic coxarthrosis and control group were observed in carriers of -166Arg genotype / Arg FCGR2A gene (χ2 - 99.2, p
Idiopathic coxarthrosis, prediction, gene, polymorphism
Короткий адрес: https://sciup.org/142201022
IDR: 142201022 | DOI: 10.18019/1028-4427-2017-23-3-331-335