Prospects of pharmacological correction of the acute cerebral ischemia

Are studied neuropretective properties of xymedon, mexidol and fumarate 3- oxypyridin on model of a global cerebral ischemia at white rats. It is established, that therapeutic application during 10-òè days of xymedon in a dose of 30 mg/kg, mexidol and fumarate 3- oxypyridin in doses of 50 mg/kg significally promotes restoration of the neurologic status of experimental animals at a bilateral occlusion of common carotids. Protective action was studied by comparison of neurologic changes at an ischemia and on a background of introduction of investigated preparations. It is proved the expressed neuroprotective effect of xymedon, mexidol and fumarate 3- oxypyridin in comparison with pyracetamum on the given model of cerebral ischemia.