Perspectives of usage osteoporosis biomarkers in diagnostics and treatment

Osteoporosis is a systemic disease characterized by decreased bone mass, deterioration of bone tissue and increased susceptibility to fracture. Today the most of osteoporosis cases are diagnosed by x-ray measuring of bone density. However, there is a tendency of using potential biomarkers for bone formation and degradation diagnostics. The current review observes the main biomarkers of bone remodeling and analyze their possible clinical use. According to the collected data, the most cited markers of bone remodeling was N- and C-collagen telopeptide, showing resorption processes and bone-specific alkaline phosphatase, which reflected the osteoblasts activity, which is increased usually after the fractures. There also was noticed a significant increase in number of published articles. Thus, further studies need to be conducted in order to create and develop new diagnostic techniques and implementing them into clinical practice. Provided with enough attention and resources, future findings will be able to rise the quality of prevention and treatment of osteoporosis.