Перспективы современных методов диагностики рака почки (обзор)
Автор: Захарова Н.Б., Комягина Ю.М., Понукалин А.Н., Никольский Ю.Е., Королев А.Ю.
Журнал: Саратовский научно-медицинский журнал @ssmj
Рубрика: Урология
Статья в выпуске: 1 т.13, 2017 года.
Бесплатный доступ
Исследованиями последних лет показано, что рак почек развивается на фоне хронического воспалительного процесса, который приводит к снижению активности дифференцировки эпителиальных клеток и усилению их пролиферации. Дальнейшее развитие рака почек связано с участием большого числа цитокинов и ростовых факторов. При этом опухолевые клетки постоянно взаимодействуют с иммунной системой. Эти процессы приводят к появлению опухолеассоциированных макрофагов, локально подавляющих противоопухолевый иммунный ответ и контролирующих опухолевый ангиогенез. В настоящее время наряду с большой группой молекулярно-генетических маркеров рассматривается возможность использования в качестве диагностических и прогностических показателей для эффективного и персонализированного лечения больных раком почки исследования опухолеассоциированных макрофагов и экспрессии различных проангиогенных факторов ангиогенеза.
Ангиогенез, рак почки
Короткий адрес: https://sciup.org/14918406
IDR: 14918406
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