The first results of comparison of blood serum proteomes of patients with schizophrenia and bipolar affective disorder

The article presents the preliminary results of a comparative proteomic analysis of blood serum proteins in patients with schizophrenia and bipolar affective disorder compared to healthy donors. As a result of mass spectrometry analysis two proteins were revealed, which are found only in patients with bipolar affective disorder: ankyrin repeat domain-containing protein 12 - 235507 Da and plectin -531466 Da. In addition, four proteins have been identified that are specific to patients with schizophrenia: protein-tyrosine kinase (Ec.2.7.10.2) - 128263 Da, haploid germ cell-specific nuclear protein 1 - 25933 Da, smooth muscle gamma actin - 41850 Da and protein with unknown functions; hypothetical protein LANCL 1 - 45711 Da. The detected proteins may be potential pathogenetic markers of these mental disorders.