Search for biological factors associated with the stability of therapeutic remission in alcohol dependence

Patients and Methods. The study included 89 male alcoholic patients with different duration of therapeutic remission. Endocrine regulation factors were determined in blood serum by the concentration of hormones (cortisol, testosterone, thyroid stimulating hormone - TSH, free triiodothyronine - T3, free thyroxine - T4) by enzyme immunoassay. Oxidative stress factors were determined in blood plasma by the concentration of carbonylated proteins using 2,4-dinitrophenylhydrazine and LPO products using thiobarbituric acid. Control - blood serum and plasma of 38 healthy male subjects. To construct a predictive model of remission stability, the method of logistic regression was used. Results. In patients with alcohol dependence, an increase in the concentration of cortisol, testosterone, carbonylated proteins, TBA-reactive products, the ratio of cortisol / testosterone, and a decrease in the levels of thyroid hormones were found. The predictive model showed that the most sensitive parameters for predicting unstable remission are the cortisol / testosterone ratio and the level of free fractions of thyroid hormones T3 and T4. Conclusion. The informative biological indicators for predicting the stability of therapeutic remission in patients with alcoholism were revealed