The search for new drugs, effective against bovine viral diarrhea virus, disease of mucous membranes of the cattle

Bovine viral diarrhea, the illness of mucous membranes of cattle is widespread in many coun-tries of the world and it is considered to be the most important disease having economic value for mod-ern animal husbandry. One of the main instruments of the fight against this infection is vaccination of animals. It allows preventing sharp disease out-breaks and embryonic mortality of a fetus, but not persistent and subclinical forms of an infection in calves. A big variety of types and subtypes estab-lished now at the virus demands creation of more effective vaccines and search of various prepara-tions and chemical compounds with the expressed antiviral activity. Now there are no effective antiviral preparations for treatment of various forms of this disease in cattle. The results of studying the effi-ciency of a new preparation concerning the causa-tive agent of viral diarrhea illness of mucous mem-branes of cattle received when carrying out the re-searches in vivo in naturally infected calves with a subclinical form of an infection are presented. When performing the study clinical, hematologic, virologic and serologichesky methods of research-es are used. The experiments were made in the calves of 3-4 months of age who are naturally in-fected with the virus with a subclinical form of an infection. The effective dose of a preparation which made 0.5 mg/kg of body weight was defined. Intranazal introduction of the preparation in this dose daily for 10 days led to the reduction of terms of allocation of the virus with nasal secrets, normal-ization of clinical condition of animals, body tem-perature and hematologic indicators. The results of serological researches of pair tests of serum of blood retrospectively confirmed etiologic role of a virus in the development in calves of a subclinical form of infection.