Clinical and immunological status indicators in the calves' diarrhea treatment with a phytoprobiotic agent

The aim of the study is to conduct a comparative analysis of clinical and some immunobiochemical parameters when using a complex phytoprobiotic agent to treat diarrhea in calves. For the experiment, two groups of newborn calves with signs of diarrhea were formed on a farm in the Zabaikalsky Region, with 10 animals in each (n = 20). From the second day of life, the calves of the experimental group were given the developed phytoprobiotic agent in the form of a solution, which included: bergenia radix root, rose hips (Surrexit coxis), chamomile flower decoction (Pyrethri flores), eleutherococcus rhizome (Rhizomede Siberian ginseng), and the probiotic Bacillus subtillis VKPM B10641 at a dose of 1.5 ml/kg of live weight twice a day at 12hour intervals; The control group of animals was given a solution of Bacillus subtillis VKPM B10641 of at least 1 · 106 CFU of live bacterial spores at a dose of 3 ml/kg once a day for 10 days. Using generally accepted methods of clinical and laboratory analysis, the calves of the experimental group after 10 days of therapy recorded: normalization of clinical and hematological parameters, an increase in the level of total protein by 32.6%, an increase in albumin by 5.4 %. In animals of the control group, probably as a result of dehydration of the body, the albumin level was reduced by 4.2 %. An increase in globulins in the blood serum of young animals was observed by 12.8 and 14.7%, respectively (P ˂ 0.05). The albuminglobulin ratio in the experimental group corresponded to the normal background (1.01.2 units). Bactericidal and lysozyme activity of blood serum increased by 8.5 and 36.6 %, respectively (P ˂ 0.01). The complex phytoprobiotic can be recommended for oral therapy both for newborn calves and in their postmilk period as an astringent, antiinflammatory and increasing nonspecific resistance of the body agent, thereby reducing the use of synthetic drugs.