Gene pleomorphism of chemokine receptor CCR5 in patients with bronchial asthma and their relatives

Family examination of 70 probands with bronchial asthma (BA) and 162 their relatives I, II, III degrees of relationship (the mainc group) was carried out. Healthy people were included in the control group (n=263). During the examination the standard complex of inspection of people with BA, molecular genetic methods of research, and also methods of statistical data processing were used. Results of research of polymorphism of a gene of chemokine receptor ССR5 in coding area in BA patients and their relatives in comparison with control group are presented. It is established that polymorphism of a gene of chemokine receptor CCR5 in coding area is associated with BA and is an important component of BA hereditary predisposition.