Polymorphism of the gene HFE is a risk factor for endometrial cancer in women of reproductive age

The association between polymorphisms in the HFE gene (homozygous and heterozygous for minor alleles 187G и 845A) and endometrial cancer risk is analyzed in 236 cases (160 endometrial cancer + 76 endometrial hyperplasia) and 112 healthy women. Genotyping was performed with PCR/RFLP assay (the PCR products are digested using appropriate restriction endonucleases and the resulting restriction fragments are separated according to their lengths by gel electrophoresis). A significant difference was observed in frequencies of polymorphic HFE alleles between the women of reproductive age and the elderly subjects (р=0,0005). The endometrial cancer risk increased for women of reproductive age with a minor alleles 187G or 845A HFE gene.