Gene polymorphism of TNF-, IL-1, INOS and features systemic in-flammatory response in patients with chronic heart failure

The study examined the influence of gene polymorphisms of TNF-ƒ, IL-1ƒ, inducible NO synthase (iNOS) (CCTTT) n at risk for and severity of heart fail-ure. In 226 patients with chronic heart failure with varying severity of the fence was made of genetic material (bukalny epithelium) and then typing alleles of TNF-ƒ, IL-1ƒ, (iNOS) (CCTTT) n at risk for and severity of heart fail-ure. Have been identified associations between polymorphisms of TNF-ƒ (G-308A), interleukin-1ƒ (C 3953 T) and gene iNOS (CCTTT) n at risk for and severity of heart failure.