Polymorphism of folate metabolism genes and risk of lung cancer

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality worldwide. Folate metabolism plays an important role in carcinogenesis through its involvement in the process of dNa methylation and repair. the aim of our study was to evaluate the relationship between MTHFR С677Т (rs1801133), MTR A2756G (rs1805087), MTRR А66G (rs1801394) gene polymorphisms and lung cancer risk. material and methods. a systematic literature search was conducted in the electronic databases pubmed, elibrary.ru in the time period between 2003 and 2018. Results. the MTHFR C677T and MTRR А66G gene polymorphisms were found to be significantly associated with lung cancer. No significant association between the MTR A2756G polymorphism and lung cancer risk was found. the variant alleles of MTR 2756A > G and MTRR 66A > G polymorphisms may have a joint effect on lung cancer risk. a number of factors, such as nationality, smoking, gender, and an accurate diagnosis can influence the results of studies on the role of genes involved in folate cycle in patients with lung cancer. conclusion. Future studies are needed to consider gene-gene and gene-environment interactions in lung cancer. Further investigations on MTHFR С677Т (rs1801133), MTR A2756G (rs1805087), MTRR А66G (rs1801394) polymorphisms and lung cancer susceptibility may provide a theoretical basis for lung cancer prevention.