The sex-specific morphological differences of mucosal layer of colon in adult C57Bl/6 mice

The morphofunctional differences of colon between sexes are not well studied. The goal of this research is to study the sexual difference of structural components of mucosal layer in different parts of colon in adult mice of C57BL/6 strain. The body mass and the length of colon were evaluated and the morphological and morphometric evaluation of mucosal layer were conducted in adult male and female mice of C57BL/6 strain. In comparison with adult females, males tended to have more body weight and longer colon. In colon mucosa, especially in the distal colon, there was greater volumetric proportion of goblet cells and other cell elements, which could reflect the greater intensity of mucosal and immunological compartments. These sex differences in hystophysiology of colon and its parts, evidently, predetermine the course of pathological processes in different parts of colon and in different sexes.