Sex-related differences in morphofunctional changes of the rat thyroid after long-term exposure to low doses of DDT during postnatal development

One of the most urgent problems in medical science is the impact of endocrine disruptors on the functioning of endocrine glands. Of particular interest to scientists are the effects of low dose exposure to a widespread endocrine disruptor dichlorodiphenyltrichloroethane (DDT) on a developing organism. Due to the antiandrogenic effect of DDT, the study of patterns and particularities of morphological and functional changes in both sexes is extremely important for understanding mechanisms of action of this endocrine disruptor. The aim of this research was to study morphofunctional changes in the thyroid and identifying gender differences in Wistar rats exposed to low doses of DDT from birth to puberty. Animals in experimental groups were given a solution of o,p-DDT at a concentration of 20mkg / L for 6 weeks instead of water. Average daily consumption of o, p-DDT was 3,71 ± 0,15pg/kg. Quantification of serum concentrations of total thyroxine (T4), free thyroxine (fT4), total triiodothyronine (T3), free triiodothyronine (fT3) were performed by ELISA, using commercially available kits (“Cusabio Biotech”, China; “Monobind”, USA)...