Production and biocompatibility evaluation of a three-dimensional bioactive matrix with specified properties based on decellularized heterologous bone tissue

The development of new implantable materials for bone regeneration remains a challenging task that is currently being considered from the perspective of tissue engineering. Such products should consist of bioactive three-dimensional matrix containing either cells or biologically active proteins, including growth factors, signaling molecules, or specific genes and/or their products. The paper presents a fragment of results obtained within studies on technology of creation and ways to achieve significant qualitative and quantitative parameters of such a matrix and studies evaluating biocompatibility in vivo using the original model of a critical bone defect.