Liver injury in acute pancreatitis of varying severity

The study included 44 patients with acute pancreatitis, who were divided into 2 groups according to severity upon hospitalization: the first group - with a mild degree, the second group - with a severe degree. The research methods included the assessment of endogenous intoxication, lipid peroxidation activity and the functional state of the liver. It was found that the early stage of acute pancreatitis is accompanied by liver dysfunction - a change in the main organ indices and modifications of the hemostasis system (hypercoagulation and hypofibrinolysis). The most important pathogenetic links in the development of liver dysfunction were homeostatic deviations (endogenous intoxication and oxidative stress) developing in the first days of the disease. This was evidenced by their association with the severity of the patients' condition. With a mild degree of severity, these disorders were reversible, and with a severe degree - persistent.