Damage, inflammation of the vascular endothelium, hypercoagulable as a risk factor for heart diseases in patients with chronic alcoholism

The study examined the markers of damage and inflammation of the vascular wall and abnormal blood coagulation in 60 patients with chronic alcoholism stage II (heavy drinkers). High-sensitive CRP (hsCRP) levels were measured by immunoturbidimetric assay with Termo Fisher reagents (Finland) and automatic biochemical analyzer Konelab 60i (Thermo Electron, Finland). Homocysteine was determined by ELISA by using Axis-Shield test system (Germany, Norway). The functional activity of von Willebrand factor (vWF) was determined by measuring ristomycin-cofactor activity (RSA) of blood plasma with Renamo test system (Russia). Level of vWF antigens were quantitively measured by ELISA with Technoclone test system (USA). Activated partial thrombin time (APTT) was determined with Platelin LS reagent (Organon Teknika Corporation). Data showed the increases in the level and activity of vWF (р