Prebiotic and cholesterol-degrading properties of sea buckthorn oil

The widespread prevalence of diseases of the cardiovascular system leads to disability and increased mortality of the population. Currently, it has been established that cardiovascular diseases and atherosclerosis are associated with a violation of the lipid metabolism of cholesterol and its fractions. Medicinal methods of treatment are of great importance in the correction of lipid metabolism disorders. One of the effective methods is the use of foods and dietary supplements that reduce cholesterol. Such products include sea buckthorn oil, which is the richest source of mono- and polyunsaturated fatty acids, and other biologically active substances that improve lipid metabolism. Probiotic microorganisms play an important role in the prevention of lipid metabolism. It is known that the microflora inhabiting the human gastrointestinal tract is actively involved in cholesterol metabolism. A change in lipid metabolism is always accompanied by a violation of the microbiome of the gastrointestinal tract. According to the research results, sea buckthorn oil helps to increase the titer of probiotic microflora and has cholesterol-degrading properties. According to the research results, sea buckthorn oil has prebiotic and cholesterol-degrading properties. The concentration of sea buckthorn oil of 3-5 % has been established, which increases the yield of biomass and at the same time the number of cells of propionic acid bacteria reaches 1012 K.O.E. in cm3, which confirms its prebiotic properties. It has been established that when propionic acid bacteria are cultivated in a nutrient medium with sea buckthorn oil, the activity of cholesterol transformation and degradation increases. The maximum amount of cholesterol is destroyed at a concentration of sea buckthorn oil of 5 % and is 75 %. It is important to note that propionic acid bacteria exhibit pronounced destructive activity in relation to cholesterol. There is a decrease in cholesterol levels in the incubation medium depending on the duration of cultivation.