Predictors of forming and clinical features of neural tube defects in children of the Kyrgyz population

Protocols of autopsies of 3931 fetuses with congenital malformations, conducted by the Republican pathoanatomical bureau, were retrospectively studied. A complete clinical and laboratory study of 50 sick children with Neural Tube Defects (NTD) was conducted prospectively. The analysis for 2008-2012 showed that amid a decrease in the number of induced births, an increase in NTD is noted. The increase is due to the deterioration of the environmental situation in the country and the improvement of the quality of antenatal diagnosis of the disease. Similar data were obtained in Russia and Kazakhstan. The rank significance of all reliable biomedical risk factors for the formation of NTD in children was determined. In the study of social risk factors, it was found that families of sick children have a significantly low social status. Highly demonstrative indicators are possessed by villagers, internal migrants with low educational qualifications and unfavourable material and living conditions. Among Kyrgyz children with NTD, the presence of the A1298C heterozygous genotype increases the risk of development by 4.71 times (OR=4.71; p=0.0079), and the presence of the 1298C allele 2.2 times (OR=2.2; p=0.04).