Preparative synthesis of N1-monosubstituted quinazoline-2,4(1H,3H)-dionederivatives

A comparative analysis of four different methods of the synthesis of N1-monosubstituted derivatives of quinazoline-2,4(1 H,3H)-dione was carried out. It has been shown that, depending on the nature of the alkylating agent, the use of quinazoline-2,4(1 H,3H)-dione or its 1,3-dibenzoyl derivative as a substrate is the most effective during the conducting of reaction in an anhydrous DMF medium in the presence of an excess of potassium carbonate at room temperature.