Preparations of the group of neuroleptics in the practice of evidence-based medicine

Neuroleptic syndrome is one of the most common complications of taking neuroleptics. The variability of symptoms and side effects from neuroleptics is very high, and in this study we planned to study which complications are most common, and in which age range they are more pronounced. This would help doctors using these drugs the most, predict who is likely to develop neurolepsy, and how to avoid side effects. The pathogenesis of neuroleptic syndrome is not completely clear, but the pharmacological properties of antipsychotics suggest that it is based on the blockade of dopamine receptors in the nigrostriatal pathway and the associated release of glutamate, leading to an imbalance of neurotransmitters, damage to the basal ganglia and subcortical-thalamic connections, as well as compensatory enhancement of dopamine synthesis and release. For the occurrence of extrapyramidal disorders, the level of binding of D2 receptors from 75% and higher is required.