Causes of stent restenosis in patients with ST elevation acute coronary syndrome after percutaneous coronary intervention

Predictors of stent restenosis were identified in 122 patients with acute coronary syndrome (ACS) ST elevation underwent percutaneous coronary intervention (PCI) with stenting within 123 months. The criterion for division into groups was the presence of repeated cases of ACS as a result of stent restenosis confirmed by coronary angiography. The first group (I) included 20 patients with stent restenosis, the second group (II) - 102 patients with ACS without complications. All patients underwent PCI on angiographic installation INNOVA 3100 (USA) at the first day of hospitalization. All the patients had their serum sP-selectin, inflammatory cytokines and C-reactive protein concentrations measured by the quantitative enzyme-linked immunosorbent assay at Day 1 and Day 10. According to the results of discriminant analysis most significant predictor of stent restenosis was a high level of tumor necrosis factor-ƒ at the 1st prior to revascularization. Years of smoking, Day 1 level of interleukine-6 and extended stenosis of coronary artery were less significant for development of stent restenosis.