Application of alpha-fetoprotein in immunopharmacology - background

The immunopharmacological potential of alpha-fetoprotein (AFP) is closely related to its ability to modulate the activity of cells of the immune system. Due to the immunomodulating properties, as well as the transport function - the transfer of low molecular weight substances, AFP is used in the treatment of a number of pathological conditions. The first attempts to use the therapeutic potential of AFP are associated with the use of extracts of embryonic tissues, with the development of technology, purified AFP from abortive material was used as a drug, and in some cases, recombinant forms of AFP were used. These drugs are intended primarily for the treatment of autoimmune as well as cancer. The review presents data on known variants of AFP dosage forms. In general, the study of the mechanisms of action of AFP at the level of the immune system is currently an urgent issue.