Application interface membrane separator mass-spectrometric analysis of anesthetic drugs in biological fluid

Described interface mass-spectrometry for measuring the anesthetic concentration in biological fluids (plasma and urine). Sampling was carried out in biological fluids during balanced inhalation (sevoflurane, fentanyl) and total intravenous anesthesia (propofol, fentanyl) anesthesia. The described technique of measuring the concentration of drugs in biological fluids requires no sample preparation for introduction of the sample into the mass spectrometer interface, which used selective hydrophobic membrane, which can allocate anesthetic drugs from biological fluids: inhalation anesthetic sevoflurane, propofol hypnotic. The possibility of using the membrane interface for absolute measurement of the absolute concentration of intravenous hypnotic propofol in blood plasma.