“Green chemistry” principles’ application in propargylation of p-phenylenediamine

A study of p-phenylenediamine propargylation in the presence of potash and tetra-n-butyl ammonium iodide as a catalyst under varying temperature (from 40 to 70 °C) and time (from 3 to 25 h) helped to define the reaction’s conditions that lead to the preferential formation of mono-, di-, tri- or tetra-propargyl derivatives of p-phenylenediamine. Column chromatography on silica by benzene, chloroform, metyl acetate, and ethyl acetate elution assisted in obtaining the samples of all individual amines. IR, NMR 1H, 13C spectra confirms their structures. The antibacterial properties of synthesized hydrochlorides of p-phenylenediamine propargylated derivatives were investigated for the first time on eight test-cultures including Escherichia coli, Salmonella gallinarum, Pasteurella multocida, Klebsiella pneumoniae 444, Mycobacterium B 5, Staphilococcus aureus 9, 3316 and Candida albicans.