Применение таргетной терапии в лечении пациентов с нейроэндокринными опухолями желудочно- кишечного тракта и поджелудочной железы

Применение таргетной терапии в лечении пациентов с нейроэндокринными опухолями желудочно- кишечного тракта и поджелудочной железы

Автор: Исянгулова А. З., Хасанов Р. Ш., Еникеев Р. Ф.

Журнал: Злокачественные опухоли @malignanttumors

Рубрика: Обзоры и аналитика

Статья в выпуске: 4 т.9, 2019 года.

Бесплатный доступ

Проблема нейроэндокринных опухолей (НЭО) стала углубленно изучаться только в последние годы. Возросшее внимание к ней обусловлено увеличением частоты обнаружения НЭО в связи с совершенствованием методов диагностики. Ограниченная эффективность химиотерапии у высокодифференцированных распространенных метастатических НЭО желудочно-кишечного тракта (ЖКТ) и поджелудочной железы (ПЖ) подчеркивает необходимость поиска новых и более эффективных вариантов лекарственного лечения. Недавние исследования специфических биологических особенностей НЭО привели к разработке новых целевых методов лечения, которые учитывают высокую васкуляризацию и гиперэкспрессию специфических факторов роста и родственных рецепторов тирозинкиназы. Таким образом, с изучением сигнальных путей mTOR TSC2, PTEN и PIK3CA открываются новые возможности в лечении пациентов с НЭО ЖКТ и ПЖ, особенно неоперабельных и метастатических форм. Таргетная терапия, которая специфически ингибирует рецепторы факторов роста и связанные с ними сигнальные пути, является многообещающим подходом лекарственного лечения НЭО ЖКТ и ПЖ. В этом обзоре кратко изложено состояние и перспективы использования таргетной терапии, описаны клинические исследования в лечении НЭО ЖКТ и ПЖ.

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Нейроэндокринная опухоль, таргетная терапия, карциноид, рак поджелудочной железы, рак желудочно-кишечного тракта

Короткий адрес: https://sciup.org/140249284

IDR: 140249284   |   DOI: 10.18027/2224-5057-2019-9-4-49-58

Список литературы Применение таргетной терапии в лечении пациентов с нейроэндокринными опухолями желудочно- кишечного тракта и поджелудочной железы

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